研究超声法提取卢豆茎中胡芦巴碱的最佳工艺条件。以胡芦巴碱的提取率为指标，采用高效液相色谱法测定样品中的胡芦巴碱含量。在单因素实验结果的基础上，选择提取温度、提取时间、超声功率和甲醇浓度4个主要影响因素进行了4因素15水平的均匀设计试验，通过SPSS统计软件分析试验结果。确定了卢豆茎中胡芦巴碱的最佳工艺条件：以48%甲醇为溶剂在64℃、120 W频率下超声波提取75 min。超声波法提取卢豆中的胡芦巴碱操作简单，用时短，提取率高。

The optimal conditions for the ultrasonic extraction of trigonelline from Trigonella coerulea was studied in the present study. Taking the yield of trigonelline as index, the content of trigonelline was determined by HPLC. On the basis of single factor experiments, the four major effect factor, including extraction temperature, the extraction time, the ultrasonic power and the methanol concentration were selected to optimize the extraction conditions using uniform design. The results were analyzed through SPSS software. The optimal conditions for trigonelline extraction were explored to be ultrasonically extracted by 48% methanol at 64℃ and 120 W ultrasonic power for 75 min. The ultrasonic extraction is efficient, rapid for trigonelline with high yield.