To investigate the effects of sowing depth and seed coating on seedling growth, yield, and quality of summer soybean, using 'Baodou 10' as the test material, a field experiment was carried out with different sowing depth (3 cm D1, 5 cm D2, 7 cm D3, 9 cm D4), and seed coating (6.25% Metalaxyl-fluoxonil T1, 30%Thiamethoxam T2, 25% Thiamethoxam methylene fluoxonil T3,no seed coating CK) with the two-factor split-plot experiment design. The results showed that seedling percentage was increased as the sowing depth increased, and seedling percentage ofseed coating treatment was better than that of no seed coating (P<0.05). The seedling percentage of T2 was the highest with a value of 77.08%. The effect of sowing depth on plant height, root length, number of roots were difference, and plant height, root length, number of roots of seed coating treatment were better than that of no seed coating. The effects of sowing depth, seed coating, and sowing depth×seed coating on SPAD and Pn of the soybean leaf was significant, and the SPAD value of D2 and T2 were higher than that of others (P<0.05) in flowering stage and pod stage. The Pn of D2 in tested stage and the Pn of T2 in flowering stage and pod stage were much higher than that of others (P<0.05). Sowing depth, seed coating, and sowing depth×seed coating had a significant effect on yield and seeds per plant (P<0.05), the yield of D2T2 was the highest with a value of 4413.48 kg/hm2. The effects of sowing depth, seed coating, and sowing depth×seed coating on protein content, fat content, and isoflavone content of the soybean seed was significant (P<0.01), and the response of quality index to tested factors was difference. Sowing depth, seed coating, and sowing depth×seed coating had a significant effect on seedling growth, photosynthetic performance, and seed quality. Sowing depth (5 cm) and seed coating of 30% thiamethoxam could improve the growth, photosynthetic performance and yield components of soybean seedlings, and finally obtain higher yield and grain quality.