Abstract: In order to establish cultivation technique model under the condition of different sowing date in different locations in Huaibei Area. Using comprehensive methods were orthogonal design method and stability evaluation based on many years and many places. The main research area was the northern region, central region and southern region in Huaibei area of Anhui Province. The results showed that, high stability of the treatment were: wheat varieties ‘Yannong 19’ and ‘Wanmai 52’; nitrogen quantity was 240 kg/hm2, ratio of base and topdressing was 5:5-4:6, planting density was 120×104-180×104 plants per hm2, Weeding hoe and spraying on leaf fertilizer "star of America" as the best course of action. For ‘Zhoumai 22’ high stability of the treatment were: nitrogen quantity was 300 kg/hm2, ratio of base and topdressing was 5:5, planting density was 180×104 plants per hm2. For production, early sowing (October 3rd) and late sowing (October 30th) had production effect, suitable sowing time was October 15th. Early sowing wheat high-yield cultivation techniques should choose winter wheat or semi-winter wheat varieties, appropriate to reduce density, Wheat repression and chemical control in the wheat turning green stage. Late sowing wheat high-yield cultivation techniques should be choose partial spring semi winter wheat varieties, increasing planting density, increase the fertilizer rate, spraying leaf fertilizer on wheat at later growth stage, in order to enhance grain grouting intensity. It will be beneficial to improve wheat yield.