Abstract: Objective:After applicating N,P,K on Typhonium trifoliatum Wang et lo ex H.li et al ,The experiment used the second universal rotary combination design of the program to discuss if the three kinds of fertilizers have a significant effect on yield of this medicinal plant as well as the interaction of the N,P,K effectting on yield.In order to set up the maths model of high-yield and low consumpion Typhonium trifoliatum Wang et lo ex H.li et al fertilization program and provide a theortical basis. Results and conclusion ：The effect of phosphorus is greater than nitrogen fertilizer,nitrogen fertilizer is greater than the potash .If the level of the phosphorus and potassium exceeding the optimal amount of fertilizer will lead to reduction of output. Single applicaion of N,P,K fertilizer,the highest yield of the three kinds of using were :408.7kg/hm2,936.2kg/hm2,302.6kg/hm2;interation effct of phosphorus and potassium has significant value ,undering the level of nitrogen fertilizer for 225 kg/hm2,the amount of phosphorus and potassium fertilizer were :1071 ,330,the largest output reach to 4791.1 kg/hm2, phosphorus and potassium alone to achieve the maximum yield ,respectively 2％,1％;Through the establishment of a data model ,that 95％confidence region ,the three kinds of fertilizer application in the optimal range,urea：289.6～335.9 kg/hm2；over phosphate:957.2～1140.44 kg/hm2；potassium sulfatehm：267.86～323.26 kg/hm2.