五味子在化妆品中的应用与前景

doi:10.11923/j.issn.2095-4050.cjas2021-0160

农学学报 ›› 2023, Vol. 13 ›› Issue (1): 44-50.doi: 10.11923/j.issn.2095-4050.cjas2021-0160

• 林学/园艺/园林/食用菌 • 上一篇下一篇

五味子在化妆品中的应用与前景

郑晓霞¹(), 赵姝婷¹, 王荣灿¹, 侯微¹^,²^,³()

¹ 中国农业科学院特产研究所，长春 130112
² 吉林省中药材及饮片加工转化科技创新中心，长春 130112
³ 吉林省中药材种植（养殖）重点实验室，长春 130112

收稿日期:2021-09-30 修回日期:2021-12-20 出版日期:2023-01-20 发布日期:2023-01-31
通讯作者: 侯微，女，1981年出生，吉林省吉林市人，副研究员，博士，研究方向：中药材抗衰老、抗氧化研究。通信地址：130112 吉林省长春市净月经济开发区聚业大街4899号中国农业科学院特产研究所，E-mail：jilinhouwei@163.com。
作者简介:
郑晓霞，女，1996年出生，辽宁丹东人，硕士研究生，研究方向：作物科学。通信地址：130112 吉林省长春市净月经济开发区聚业大街4899号中国农业科学院特产研究所，E-mail：18241588397@139.com。
基金资助:
吉林省科技发展计划项目“以五味子藤茎为基源的系列化妆品开发”(20210204069YY)

The Application and Prospect of Schisandra chinensis in Cosmetics

ZHENG Xiaoxia¹(), ZHAO Shuting¹, WANG Rongcan¹, HOU Wei¹^,²^,³()

¹ Institute of Special Animal and Plant Sciences of CAAS, Changchun 130112, Jilin, China
² Jilin Provincial Science and Technology Innovation Center of Traditional Chinese Medicine Materials & Slices Processing and Conversion, Changchun 130112, Jilin, China
³ Jilin Provincial Key Laboratory of Traditional Chinese Medicinal Materials Cultivation and Propagation, Changchun 130112, Jilin, China

Received:2021-09-30 Revised:2021-12-20 Online:2023-01-20 Published:2023-01-31

摘要/Abstract

摘要：

随着中药被广泛的研究和开发，越来越多的中药有效成分出现在养肤护肤的化妆品产品中。五味子作为东北道地药材，可药食两用，具有多种保健和治疗作用。近年来，随着对五味子活性成分的不断深入探索和研究，其药食保健作用受到了公众和学术界的广泛关注。文献研究表明五味子中木脂素、挥发油、有机酸和多糖类等天然成分能较好的清除自由基，可增强机体抗氧化能力延缓衰老等，但其在化妆品领域中的研究相对较少，因此本研究对五味子在化妆品方面的应用进行了综述，为五味子在化妆品中的开发和应用提供理论依据。

关键词: 五味子, 化妆品, 木脂素, 抗氧化, 抗衰老, 活性成分

Abstract:

With the extensive research and development of traditional Chinese medicine, more and more effective ingredients of traditional Chinese medicine are used in cosmetic products for skin care. Schisandra chinensis, as a genuine medicinal material in northeast China, can be used for both medicine and food, and has a variety of health and therapeutic effects. In recent years, with the continuous in-depth exploration and research of the active ingredients of S. chinensis, its medicinal and food health effects have received extensive attention from the public and academic circles. Literature studies show that the natural components such as lignans, volatile oils, organic acids and polysaccharides in S. chinensis have good free radical scavenging effects, which can enhance the body’s antioxidant capacity and delay aging. However, the research on the application of S. chinensis in cosmetics is relatively insufficient. Therefore, this article reviewed the application of S. chinensis in cosmetics to provide a theoretical basis for its development and application.

Key words: Schisandra chinensis, cosmetics, lignans, antioxidant, anti-aging, active ingredients

郑晓霞, 赵姝婷, 王荣灿, 侯微. 五味子在化妆品中的应用与前景[J]. 农学学报, 2023, 13(1): 44-50.

ZHENG Xiaoxia, ZHAO Shuting, WANG Rongcan, HOU Wei. The Application and Prospect of Schisandra chinensis in Cosmetics[J]. Journal of Agriculture, 2023, 13(1): 44-50.

图/表 1

参考文献 63

[1]	KUMAR S. Exploratory analysis of global cosmetic industry: major players, technology and market trends[J]. Technovation, 2004, 25(11):1263-1272. doi: 10.1016/j.technovation.2004.07.003 URL
[2]	高薇. 五味子对UVB辐射人皮肤细胞损伤的保护机制[D]. 北京: 中国农业科学院, 2015:17-25.
[3]	郭苗苗. 五味子总素消炎祛痘物质基础及作用机制研究[D]. 上海: 华东理工大学, 2017:13-14.
[4]	吴志韵, 唐青涛, 车飙, 等. 五味子提取物、其制备方法及其在化妆品中的应用[P]. 中国专利, CN109984974A, 2019-05-13.
[5]	邢楠楠, 屈怀东, 任伟超, 等. 五味子主要化学成分及现代药理作用研究进展[J]. 中国实验方剂学杂志, 2021, 27(15):210-218.
[6]	张媛媛. 五味子抗菌物质的提取、抑菌机理及在食品中的应用研究[D]. 石家庄: 河北科技大学, 2016:1-4.
[7]	刘艳, 陈张林, 吴丹丹, 等. 五味子藤茎中萜类和木脂素类成分的研究[J]. 中成药, 2021, 43(6):1484-1493.
[8]	马艳春, 冯天甜, 韩宇博, 等. 五味子的化学成分和药理研究进展[J]. 中医药学报, 2020, 48(11):67-71.
[9]	石新卫, 路强强, 李晓君, 等. 华中五味子藤茎化学成分及其抗氧化活性[J]. 西北林学院学报, 2020, 35(5):207-212.
[10]	LIU G Z, LIU Y, SUN Y P, et al. Lignans and terpenoids from the leaves of Schisandra chinensis[J]. Chemistry & biodiversity, 2020, 17(4).
[11]	谷艳菲, 闫伯前, 丁轲, 等. 纯化作用对五味子木脂素抗氧化性的影响[J]. 林业科学, 2015, 51(9):96-105.
[12]	李铂, 唐志书, 许洪波, 等. 不同成熟期北五味子质量初步评价[J]. 中成药, 2020, 42(11):3084-3087.
[13]	CHEN X, TANG R, LIU T, et al. Physicochemical properties, antioxidant activity and immunological effects in vitro of polysaccharides from Schisandra sphenanthera and Schisandra chinensis[J]. International journal of biological macromolecules, 2019, 131:744-751. doi: 10.1016/j.ijbiomac.2019.03.129 URL
[14]	王洁, 路娇娇, 杜涵, 等. 五味子果肉和种子精油的化学成分与生物活性对比研究(英文)[J]. 林产化学与工业, 2019, 39(6):59-67.
[15]	TENG H, LEE W. Antibacterial and antioxidant activities and chemical compositions of volatile oils extracted from Schisandra chinensis Baill. Seeds using simultaneous distillation extraction method, and comparison with Soxhlet and microwave-assisted extraction[J]. Bioscience, biotechnology, and biochemistry, 2014, 78(1):79-85. doi: 10.1080/09168451.2014.877815 URL
[16]	金银萍, 曲正义, 崔丽丽, 等. 五味子不同部位黄酮和酚酸类成分的含量测定及抗氧化活性[J]. 中国实验方剂学杂志, 2018, 24(19):79-84.
[17]	AGNIESZKA S, MICHAŁ D, SEBASTIAN G, et al. Schisandra rubriflora plant material and in vitro microshoot cultures as rich sources of natural phenolic antioxidants[J]. Antioxidants (Basel, Switzerland), 2020, 9(6):488.
[18]	林雄平, 曾思颖, 彭彪, 等. 南五味子根黄酮提取物的抗菌抗氧化活性[J]. 安徽农业科学, 2019, 47(4):173-175,180.
[19]	宫莉, 李彤辉, 包雪, 等. 北五味子黄酮提取及其生物活性研究[J]. 长春工业大学学报, 2015, 36(5):556-561.
[20]	NAMKOONG J, KERN D, KNAGGS H E. Assessment of human skin gene expression by different blends of plant extracts with implications to periorbital skin aging[J]. International journal of molecular sciences, 2018, 19(11):3349. doi: 10.3390/ijms19113349 URL
[21]	马莹慧, 冯波, 朱鹤云, 等. 北五味子中总木脂素类成分的抗氧化及抗炎活性研究[J]. 食品研究与开发, 2019, 40(11):25-30.
[22]	马莹慧, 于连婷, 杨丽恒, 等. 北五味子中总木脂素类成分的纯化工艺及抗氧化作用研究[J]. 中华中医药学刊, 2019, 37(12):2901-2905.
[23]	YAN T, SHANG L, WANG M, et al. Lignans from Schisandra chinensis ameliorate cognition deficits and attenuate brain oxidative damage induced by D-galactose in rats[J]. Metabolic brain disease, 2016, 31(3):653-661. doi: 10.1007/s11011-016-9804-3 URL
[24]	ZHANG R, WANG Y, ZHU D, et al. The protective effect of North Schisandra Lignans on vascular endothelial cell oxidation injuries[J]. Technology and health care: Official journal of the european society for engineering and medicine, 2016, 24(Suppl 2):S651-7.
[25]	CHOI Y H. Schisandrin A prevents oxidative stress-induced DNA damage and apoptosis by attenuating ROS generation in C2C12 cells[J]. Biomedicine & pharmacotherapy, 2018, 106:902-909.. doi: 10.1016/j.biopha.2018.07.035 URL
[26]	GAO C, CHEN H, NIU C, et al. Protective effect of Schizandrin B against damage of UVB irradiated skin cells depend on inhibition of inflammatory pathways[J]. Bioengineered, 2017, 8(1):36-44. pmid: 27689692
[27]	侯微, 魏忠宝, 高薇, 等. 五味子甲素·乙素及丙素对HaCat细胞氧化损伤的保护作用研究[J]. 安徽农业科学, 2013, 41(3):1047-1049.
[28]	DING M, SHU P, GAO S, et al. Schisandrin B protects human keratinocyte-derived HaCaT cells from tert-butylhydroperoxide-induced oxidative damage through activating the Nrf2 signaling pathway[J]. International journal of molecular medicine, 2018, 42(6):3571-3581.
[29]	邱明阳, 赵武, 刘玉婷, 等. 五味子抗氧化及抑制α-葡萄糖苷酶活性的比较研究[J]. 天然产物研究与开发, 2018, 30(05):840-846.
[30]	朱力杰. 北五味子总三萜、木脂素对酒精性肝损伤的保护作用及其机制的研究[D]. 沈阳: 沈阳农业大学, 2014:35-44.
[31]	李珊珊, 祁玉丽, 华梅, 等. 北五味子多糖的分离纯化及抗氧化活性研究[J]. 食品工业, 2018, 39(4):233-237.
[32]	YUE C, CHEN J, HOU R, et al. The antioxidant action and mechanism of selenizing Schisandra chinensis polysaccharide in chicken embryo hepatocyte[J]. International journal of biological macromolecules, 2017, 98:506-514. doi: 10.1016/j.ijbiomac.2017.02.015 URL
[33]	NIU J, XU G, JIANG S, et al. In Vitro Antioxidant activities and anti-diabetic effect of a polysaccharide from Schisandra sphenanthera in rats with type 2 diabetes[J]. International journal of biological macromolecules, 2017, 94(Pt A):154-160. doi: 10.1016/j.ijbiomac.2016.10.015 URL
[34]	李振, 孟宪纬, 管延珍, 等. 南、北五味子提取物的抑菌及抗氧化作用研究[J]. 中国调味品, 2017, 42(1):28-30.
[35]	林雄平, 韩君, 彭彪, 等. 南五味子根茎叶乙醇提取物的抗菌及抗氧化活性[J]. 宁德师范学院学报(自然科学版), 2018, 30(4):402-406.
[36]	林雄平, 林彬彬, 卓雄标, 等. 南五味子果实多糖和脂溶性物质抗菌抗氧化作用研究[J]. 安徽农业科学, 2017, 45(4):119-121,168.
[37]	SONG L, CUI S, LI T, et al. Antibacterial effects of Schisandra chinensis extract on Staphylococcus aureus and its application in food[J]. Journal of food safety, 2018, 38(5).
[38]	石亚丽. 植物源抗菌物质的提取、抑菌效果及其应用的研究[D]. 石家庄: 河北科技大学, 2014:11-15.
[39]	GUO M, LU Y, YANG J, et al. Inhibitory effects of Schisandra chinensis extract on acne-related inflammation and UVB-induced photoageing[J]. Pharmaceutical biology, 2016, 54(12):2987-2994. doi: 10.1080/13880209.2016.1199041 URL
[40]	CUI S M, LI T, WANG Q, et al. Antibacterial effects of Schisandra chinensis extract on Escherichia coli and its applications in cosmetic[J]. Current microbiology, 2020, 77(5):865-874. doi: 10.1007/s00284-019-01813-6 URL
[41]	HAKALA E, HANSKI L, UVELL H, et al. Dibenzocyclooctadiene lignans from Schisandra spp. selectively inhibit the growth of the intracellular bacteria Chlamydia pneumoniae and Chlamydia trachomatis[J]. The Journal of antibiotics: Official journal of the Society for Actinomycetes, Japan, 2015, 68(10):609-614.
[42]	KANG Y S, HAN M H, HONG S H, et al. Anti-inflammatory effects of Schisandra chinensis (turcz.) baill fruit through the inactivation of nuclear factor-κb and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated murine macrophages[J]. Journal of cancer prevention, 2014, 19(4):279-287. doi: 10.15430/JCP.2014.19.4.279 URL
[43]	GUO M, AN F, WEI X, et al. Comparative effects of Schisandrin A, B, and C on acne-related inflammation[J]. Inflammation, 2017, 40(6):2163-2172. doi: 10.1007/s10753-017-0656-8 pmid: 28875271
[44]	GUO M, LU Y, YANG J, et al. Inhibitory effects of Schisandra chinensis extract on acne-related inflammation and UVB-induced photoageing[J]. Pharmaceutical biology, 2016, 54(12):2987-2994. doi: 10.1080/13880209.2016.1199041 URL
[45]	JUNG L H, SUZY J, JEONGHYUN R, et al. Effects of Schisandra chinensis Turcz. fruit on contact dermatitis induced by dinitrofluorobenzene in mice[J]. Molecular medicine reports, 2015, 12(2):2135-2139. doi: 10.3892/mmr.2015.3618 URL
[46]	LI Y Z, REN S, YAN X T, et al. Improvement of Cisplatin-induced renal dysfunction by Schisandra chinensis stems via anti-inflammation and anti-apoptosis effects[J]. Journal of ethnopharmacology, 2018, 217:228-237. doi: 10.1016/j.jep.2018.01.033 URL
[47]	OH S Y, KIM Y H, BAE D S, et al. Anti-Inflammatory Effects of gomisin N, gomisin J, and Schisandrin C Isolated from the Fruit of Schisandra chinensis[J]. Japan society for bioscience, biotechnology, and agrochemistry, 2014, 74(2):285-291.
[48]	KYOUNG C J, LALITA S, MINSUN J, et al. Gomisin N inhibits melanogenesis through regulating the pi3k/akt and mapk/erk signaling pathways in melanocytes[J]. International journal of molecular sciences, 2017, 18(2):471. doi: 10.3390/ijms18020471 URL
[49]	LEE J N, RYU H S, KIM J M, et al. Anti-melanogenic effect of gomisin N from Schisandra chinensis (Turcz.) Baillon (Schisandraceae) in melanoma cells[J]. Archives of pharmacal research, 2017, 40(7):807-817. doi: 10.1007/s12272-017-0903-4 URL
[50]	NARUKAWA Y, KOMATSU C, YAMAUCHI R, et al. Two new lignans and melanogenesis inhibitors from Schisandra nigra[J]. Journal of natural medicines, 2016, 70(3):460-466. doi: 10.1007/s11418-016-1000-6 URL
[51]	ZHAO N, SU X, LI H, et al. Schisandrin B inhibits α-melanocyte-stimulating hormone-induced melanogenesis in B16F10 cells via downregulation of MAPK and CREB signaling pathways[J]. Bioscience, biotechnology, and biochemistry, 2021, 85(4):834-841. doi: 10.1093/bbb/zbaa100 URL
[52]	GAO D, QU Y, WU H. Inhibitory effects of schisantherin F from Schisandra propinqua subsp. sinensis on human melanoma A375 cells through ROS-induced mitochondrial dysfunction and mitochondria-mediated apoptosis[J]. Natural product research, 2020, 34(10):1486-1489. doi: 10.1080/14786419.2018.1509332 URL
[53]	OH E, JANG J, CHOI Y, et al. Inhibitory effects of 1-O-methyl-fructofuranose from Schisandra chinensis fruit on melanogenesis in B16F0 melanoma cells[J]. Journal of ethnopharmacology, 2010, 132(1):219-224. doi: 10.1016/j.jep.2010.08.010 URL
[54]	YAN Z F, GUO J, TIAN F H, et al. Active compounds from Schisandra chinensis exhibiting tyrosinase activity and melanin content inhibition in B16 melanoma cells[J]. The Korean society for biotechnology and bioengineering, 2015, 20(4):814-823.
[55]	王金会. 一种中草药化妆品及其制备方法[P]. 中国专利, CN110075048A, 2019-08-02.
[56]	王红, 杨广群. 含有五味子提取物的化妆品组合物及美白滋养霜[P]. 中国专利,CN201410114954.5, 2014-06-18.
[57]	王发强, 曹波, 陈虹, 等. 五味子中木脂素类在制备防晒护肤品中的应用[P]. 中国专利, CN101612106, 2009-12-30.
[58]	赵鑫, 胡国胜, 卢艳花, 等. 五味子总素在制备抗光老化或祛痘消炎化妆品或外用药中的用途[P]. 中国专利, CN104546611A, 2015-01-14.
[59]	周有财. 一种含五味子提取物的护肤品及其制备方法[P]. 中国专利, CN111803411A, 2020-10-23.
[60]	KIM T, OH S K. Cosmetic composition useful for eliminating occurrence of skin troubles of synthetic preservatives, comprises lip balm composed of oats, Schisandra chinensis, paprika and agar and natural preservatives composed of vitamin E as main material[P]. 韩国专利, KR2021026050-A, 2021-03-10.
[61]	HWANG E T. Producing solid Schisandra chinensis concentrate useful in food materials and cosmetic materials, comprises crushing Schisandra chinensis, mixing with ethanol and extracting active ingredient from Schisandra chinensis by ultrasonic waves[P]. 韩国专利, KR2021047412-A, 2021-04-30.
[62]	SIK J, PARK J S, HONG E, et al. Cosmetic composition comprises hydrophilic composite agent comprising emulsion emulsified with emulsifier, hydrophilic composite agent is anti-aging agent including jichi root extract, Schisandra chinensis extract and liquorice root extract[P]. 韩国专利, KR2021026550-A, 2021-03-10.
[63]	HUANG Y, LI H, ZHANG Q, et al. Preparing the fermented extract of Schisandra gum red yeast for use in cosmetics, comprises crushing schisandra schisandra and mixing it with water, performing pasteurizing treatment[P]. 中国专利, CN112315867-A, 2021-02-05.

主要有效成分	类别	作用
五味子甲素，五味子乙素，五味子丙素	木脂素类	具有抗脂质过氧化作用并对细胞的氧化损伤均具有一定的保护作用，对黑色素生成也有一定的抑制作用和抗炎作用
五味子醇甲，五味子醇乙	木脂素类	具有抑菌作用
戈米辛N	木脂素类	可抑制黑色素生成
五味子酚	木脂素类	对癌细胞具有较强的细胞毒性
五味子苷E	木脂素类	具有一定的抗氧化活性
粗多糖	多糖类	具有较好的抗氧化活性
萜类，芳香族	挥发油类	具有一定的抗菌作用，调节中枢神经系统，增强机体的防御能力，有一定的毒副作用
黄酮	其他	具有较强清除超氧阴离子自由基和羟自由基的能力
有机酸	其他	具有一定的抗氧化活性
三萜类	其他	有抗HIV、抗肿瘤作用

主要有效成分	类别	作用
五味子甲素，五味子乙素，五味子丙素	木脂素类	具有抗脂质过氧化作用并对细胞的氧化损伤均具有一定的保护作用，对黑色素生成也有一定的抑制作用和抗炎作用
五味子醇甲，五味子醇乙	木脂素类	具有抑菌作用
戈米辛N	木脂素类	可抑制黑色素生成
五味子酚	木脂素类	对癌细胞具有较强的细胞毒性
五味子苷E	木脂素类	具有一定的抗氧化活性
粗多糖	多糖类	具有较好的抗氧化活性
萜类，芳香族	挥发油类	具有一定的抗菌作用，调节中枢神经系统，增强机体的防御能力，有一定的毒副作用
黄酮	其他	具有较强清除超氧阴离子自由基和羟自由基的能力
有机酸	其他	具有一定的抗氧化活性
三萜类	其他	有抗HIV、抗肿瘤作用

五味子在化妆品中的应用与前景

The Application and Prospect of Schisandra chinensis in Cosmetics

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