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农学学报

农学学报 ›› 2013, Vol. 3 ›› Issue (7): 40-43.

• 畜牧 兽医 水产 • 上一篇    下一篇

和田羊小花棘豆中毒与血液生化指标的相关性研究

王帅 贾琦珍 陈根元 张玲 马春晖   

  • 收稿日期:2013-04-27 修回日期:2013-05-30 出版日期:2013-07-20 发布日期:2013-07-20
  • 基金资助:
    新疆小花棘豆SW人工抗原合成及免疫学效应研究

Study on Correlation between Serum Biochemical Indexes and Oxytropis glabra DC Poisoning in Hetian Sheep

  • Received:2013-04-27 Revised:2013-05-30 Online:2013-07-20 Published:2013-07-20

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摘要： 为了探讨和田羊血清生化指标与小花棘豆中毒(Oxytropis glabra DC Poisoning，OgP)的关系，为和田羊小花棘豆中毒的诊治提供依据。分别以6只小花棘豆中毒和田羊与8只正常和田羊为研究对象，检测血清中谷草转氨酶(AST)、谷丙转氨酶(ALT)、碱性磷酸酶(AKP)、乳酸脱氢酶(LDH)、α-甘露糖苷酶(AMA)活性以及尿素氮(BUN)、肌酐(CR)、血糖(GLU)、甘油三酯(TG)、总胆固醇(TC)、总蛋白(TP)、白蛋白(ALB)、球蛋白(GLO)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)和极低密度脂蛋白(VLDL-C)含量。采用t检验对两组资料进行差异显著性比较后，再采用简单相关分析方法对各指标与小花棘豆中毒的关系进行分析。结果表明：与正常对照相比，小花棘豆中毒家兔血清的AST、ALT、AKP、LDH、BUN、CR、GLU、TC、GLO、LDL-C和VLDL-C值升高，AMA、TG、ALB值下降，部分组间差异显著或极显著(P＜0.05或P＜0.01)，TP和HDL-C含量差异不显著(P＞0.05)。与小花棘豆中毒相关的主要因素有AMA、GLU、LDH、AKP、TG、CR，并建立回归方程：OgP=0.681-0.073AMA+0.055GLU+0.036LDH+0.041AKP。血清AMA、GLU、LDH、AKP、TG和CR对和田羊小花棘豆中毒的早期诊断、治疗、疗效观察和转归判断具有重要意义。

关键词: 文献计量学, 文献计量学, 研究现状, 土壤微生物, Web of Science, 环境

Abstract: To analyze the relationship between twenty serum biochemical indexes and Oxytropis glabra DC poisoning in Hetian Sheep, and to provide the basis for the clinical diagnosis and treatment of Oxytropis glabra DC poisoning in animals. The activities of AST (aspertate aminotransferase), ALT (alanine aminotransferase), AKP (alkaline phosphatase), LDH (lactate dehydrogenase), AMA (α-mannosidase)and concentration of BUN (blood urea nitrogen), CR(creatinine), GLU(glucose), TG(triglyceride), TC(total cholesterol), TP(total protein), ALB(albumin), GLO(globulin), HDL-C(high-density lipoprotein cholesterol), LDL-C(low-density lipoprotein cholesterol), VLDL-C(very low-density lipoprotein cholesterol) were detected in sera of 6 sheep cases poisoning of Oxytropis glabra DC and 8 normal sheep as control. The t test was used to analyze differences of the biochemical indexes between the poisoning sheep and control, then the simple correlation method was used to analyze the relationship between indexes and poisoning by Oxytropis glabra DC. The results demonstrated that an increase of AST, ALT, AKP, LDH, BUN, CR, GLU, TC, GLO, LDL-C and VLDL-C in poisoning group, while a decrease of AMA, TG and ALB in poisoning group, with significant differences between the experimental groups (P＜0.05 or P＜0.01), the content of TP and HDL-C were not significantly lower than control group(P＞0.05). The main indexes relating with Oxytropis glabra DC poisoning(OgP) disease were the activity of AMA, GLU, LDH, AKP, TG and CR, and the stepwise regression equation was as follows: OgP=0.681-0.073AMA+0.055GLU+0.036LDH+0.041AKP. The biochemical indexes including the concentrations of AMA, GLU, LDH, GLO, TG and CR were of great importance in the early clinical diagnosis, treatment, curative effect observation and outcome judgments of Oxytropis glabra DC poisoning in Hetian Sheep.

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