Abstract: In this paper, farmland environment, the non-point source pollution, farmland soil degradation and influence of environment change on food production in Jilin province were analyzed. The reasons for the major meteorological disasters, non-point source pollution and land degradation were reviewed. Grain production fluctuation rule and economic losses caused by natural disasters on agricultural production were analyzed for 30 years. On this basis, the key technologies of sustainable food production were put forward in order to improve farmland ecological environment, increase food quality and guarantee the sustainable development of grain production. Our opinions were that scientific fertilization, improving the utilization rate, increasing soil organic matter and improving cultivated land productivity were the key to solve grain sustainable development.