Abstract: In order to carry out of the Kasugamycin WP and conventional chemical pesticides, a comparative study in the prevention and treatment of major diseases of the japonica. Separate administration of Kasugamycin WP and conventional chemical pesticides in rice growth period, and then study the effect of Kasugamycin WP and conventional chemical pesticides to control the main diseases of the japonica. The results showed that, 2% Kasugamycin WP in the blast and false smut control effect than other agents, sheath blight control effect below to take the enemy's steady 75% WG and 300 g/L Armure EC. The comparison of applied agent cell yield, 2% Kasugamycin WP slightly lower than take the enemy's steady 75% WG and 300 g/L Armure EC. Kasugamycin WP in japonica disease control effect as much as conventional chemical pesticides, since the Kasugamycin WP lower on the environment and human and animal hazards, with a high use value.