Abstract: In order to increase crop drought tolerance and crop yield, the author conducted screening of 16 complex drought tolerance agents in wheat basing on seed germination, young seedling and heading stages with indexes, such as seed germinating energy, germination percentage, dry matter weight, chlorophyllose fluorescent parameters and yield. The results showed that: Kh-13 and Kh-1 were better agents, they increased seed germination and dry matter weight, improved drought tolerance and photosynthesis, increased wheat yield. Compared with control, Kh-13 and Kh-1 increased seed germinating energy by 2.00 and 1.66 times, germination percentage by 50% and 50%, shoot weight increased by 12.33% and 11.42%, root weight increased by 19.13% and 13.0%, relative leaf water content improved 23.53% and 37.78%, grains/spike increased by 22.36% and 17.30%, yield increased by 38.48% and 20.78%, respectively.