Abstract: Wheat flag smut was the main disease of wheat in north China. Recently, it was recovered and seriously damaged in some areas. To control persistently the devastating disaster caused by the wheat flag smut, resistance-disease identification of varieties and multiple comparison of chemical tests at three sites were conducted. Eleven varieties,‘Jinmai 31’,‘Jinmai 32’,‘Jinmai 33’,‘Linyou 145’,‘Linkang 20’,‘Yunhan 618’,‘Yun 94-32’,‘Yumai 57’,‘Yannong 19’,‘Zhengmai 9023’and‘Jimai 32’, highly resistance or middle resistance to wheat flag smut, were identified from 207 spreading varieties (lines). Using multiplerepetition in three sites, five chemicals, involving triadimenol, triadimefon, carbendazim, thiophanate-methyl and dimethomorph, were selected to substitute for quintozene. The research proved that wheat flag smut can be controlled persistently by chemical seed dressing combined with resistance-disease varieties.