Abstract: In order to develop a formulation for controlling rice plant hopper and wheat aphid, the optimal ratio of pymetrozine sulfonate and dinotefuran was determined by co-toxicity coefficient method, and the optimal formulation was confirmed by selecting the adjuvant systems. The control efficacy of pymetrozine sulfonate·dinotefuran 25% OD against rice plant hopper and wheat aphid in field was tested. The superior composition consisted of pymetrozine sulfonate 12.5%, dinotefuran 12.5%, 601# 8%, T-80 9%, 5% SP SC-3, modified soil 4% , methyl oleate was up to 100% . The field control efficacy trials showed that: pymetrozine sulfonate dinotefuran 25% OD had comparatively faster availability and higher activity than the control formulation. Therefore, pymetrozine sulfonate dinotefuran 25% OD could meet the requirements of OD, and had excellent control effect against rice plant hopper and wheat aphid.