Abstract: To control weeds in wheat stubble millet field, reduce weeds influence on millet and the weeding cost, the effect of different pre- emergence herbicides and soil tillage methods on weeds and biological characters of wheat stubble millet are studied with randomized block design. The results showed that: the number of new weeds after 15, 15-30, 30-45 d was 64.77%, 26.14%, 9.09% of that of 45 d in south Shanxi; 2100 g/hm2 of 10% Monosulfuron with soil sealing had dramatic suppressing effect on new weeds of 15, 15-30 d and weeds in whole growth period; 1500 and 1800- 2400 g/hm2 of 10% Monosulfuron had respectively promoting and inhibitory effect on biological characters (plant height, individual plant secondary roots) at millet seedling stage. In conclusion, 2100 g/hm2 of 10% Monosulfuron with soil sealing can significantly inhibit weeds in wheat stubble millet field.