Abstract: To stabilize and improve plum production benefits, using organic selenium-enriched liquid fertilizer produced by Longxing Chemical Co., Ltd, of Changsha, we determine the selenium enrichment effect of the fertilizer on plums at maturity by applying different dosages at different periods of plum growth. The results showed that: during fruit enlargement period (when fruit size was 5 mm), by spraying selenium- enriched organic fertilizer at 3000 mL/hm2, 3750 mL/hm2 by adding 450 kg water on the plum leaves evenly, the content of selenium in mature plum pulp could be enriched to 0.0255, 0.0296 mg/kg, respectively, meeting the national standards of selenium- enriched fruit, at the same time, soluble solids, vitamin C, and soluble sugar were increased, fruit shape and commodity were improved. The specific application method is: during fruit enlargement period (fruit size of 5 mm), spraying selenium-enriched organic fertilizer at 1500 mL/hm2 with 450 kg water evenly on plum leaves, and spraying 1 more time after 15 days. The method can stabilize and improve the production benefits of selenium- enriched plums, and promote the targeted poverty alleviation in plum producing areas such as hilly regions and mountainous areas.