Abstract: The quantitative measurement indicator system is established base on the feature of land use structure and regional actual in order to scientific analysis the level of coordination of land use structure and regional economic development. Base on the land change survey data and socio-economic data for the corresponding time points of Haikou in 2011,the system conducts measure from six indicators including the degree of land development utilization,intensive degree and comprehensive benefits,combination type, the degree of diversification, the degree of centralization and regional index.The results show that the analysis results of indicators measure is consistent with the region actual,and measurement indicator system established base on regional land use characteristics is reasonable from the result of mutual authentication of different indicator. According to economic development situation of Haikou city district and land use combination type results of each district,The study finds Haikou domain can be divided 3 mixed-use zones base on similarity situation of land use：zone of concentrated and intensive use of construction land,zone of types of land diverse and development moderately, and zone of land type concentrated.