Abstract: In order to deeply understand the edible safety of genetically modified soybean, the development and application status of transgenic crops at home and abroad were introduced. From the three aspects of nutrition, toxicology and allergy, the study summed up the research status of food safety of genetically modified soybean. The authors proposed that the society should uphold a scientific attitude, regard the experiment as a means of research and use data to come to the conclusion. Transform body and lines should be used as the case for the application of safety certificate, and then systematical safety assessment for the transgenic organisms should be carried out. The authors also suggested further strengthening nutrition accumulation of edibletransgenic soybeans, and introducing the research on the effects of gene on metabolic hormone secretion and allergy.