Abstract: In order to clarify the N, P, K nutrient needs and their interaction mechanism in broccoli‘Luxiong 90’, and to confirm the optimum fertilization scheme for improving quality and production efficiency,‘3414’design was carried out with three factors (N, P, K) in the present study. The results showed that the nutrient needs of N, P, K changed in a parabolic curve through the growth of‘Luxiong 90’, and the overall nutrient needs of N, P, K presented a power function change through the growth. The mathematical model of broccoli harvest index (H) was: H=-0.000052M2 0.091585M 6.504614 (n=14, r=0.7057**). By analyzing the above model and the structure proportion of N, P, K in coastal areas of east Zhejiang Province, the optimal N P K interaction combination was obtained as 881 kg/hm2, including N 489 kg, P2O5 191 kg, K2O 201 kg. Therefore, this fertilization scheme could reduce the fertilizer amount by 8%. The study has certain guiding significance to change the traditional way of vegetable fertilization.