Abstract: Now the frequency of wheat gibberellic disease occurrence is high in Jianhu of Jiangsu Province, and the control efficiency of the main prevention drug—carbendazim and its mixtures is declining year after year. So the author put forward a new view of drug prevention for controlling wheat gibberellic disease in large area. Three ways were used to improve the drug prevention of wheat gibberellic disease, including increasing the availability of polyketone, reducing the dosage of carbendazim, and selecting new substitute combination of polyketone. The results showed that, 40% polyketone 1500 g/hm2 with 225 kg water had the control efficiency of disease index as 65.24%; and it was similar to the efficiency of 40% polyketone 2250 g/hm2 with 300 kg water (68.43% ). 40% polyketone 1500 g/hm2 mixed with 5% white vinegar 1500 mL/hm2 had the control efficiency of disease index as 71.04%, better than that of 2250 g/hm2 of 40% polyketone (68.43%). The control efficiency of disease index of the new drug combination was 84.71% , which was higher than that of the conventional drug 40% polyketone 2250 g/hm2 (68.43%). The increasing effect of theoretical yield was 12.83%. The results indicated that the controlling of water could improve the utilization of polyketone, adding the additives could reduce the dosage of polyketone, and the use of new combination could increase the control efficiency and yield.