Abstract: To determine the scientific fertilization technology of melon, achieve high yield and good quality, a field experiment was conducted to study the influence of different fertilizer proportions on yield, SPAD, vitamin C (Vc), sugar and nutrient accumulation of melon. The results showed that the yield under the application of controlled release urea with potassium sulfate was the highest, which reached 102.69 t/hm2. Compared with the control group, the content of heart sugar and side sugar was 16.97% and 9.90%, respectively, increased by 35.54% and 33.78%; the content of Vc was 60.86 mg/kg, increased by 31.44%; the accumulation amounts of nitrogen, phosphorus and potassium increased by 26.86%, 35.54% and 27.76%, respectively. The treatment of potassium sulfate compound fertilizer (15-15-15) 600 kg/hm2 and controlled release urea (44%) 300 kg/hm2 used as basic fertilizer, and 300 kg/hm2 potassium sulfate as topdressing at fruit expansion period could promote the absorption and utilization of nitrogen, phosphorus and potassium and improve the yield and quality.