Abstract: In order to effectively recycle the waste residue produced in factory production, achieve reasonable control of production costs, thereby enhancing production efficiency, in this experiment, the factory Pleurotus eryngii a mushroom as material after elimination, according to the different proportion of replacement of cottonseed shell and corncob cultivation of P. geesteranus, formulation screening, in order to obtain the most suitable P. geesteranus growth proportion formula. Test results showed that, eryngiibacterial chaff added had no significant influence on the agronomic traits of fruiting bodies of P. geesteranus. With the gradual increase in the proportion of residues, yield and output and value ratio of P. geesteranus showed a gradual increasing trend. With the addition of 50% P. eryngii formulation material cultivation, the yield, output value and yield ratio were the highest, and had widely application prospect.