Abstract: On the basis of the atmospheric sounding data from 1957 to 2016 and soft-shelled turtle breeding data from 2011 to 2016 in Nanfeng County, climatic elements relating with soft-shelled turtle breeding were analyzed with linear climatic tendency rate and correlation analysis. The results showed that the intervals between the initial and final days with temperature higher than 15, 20, 25℃, accumulated temperature, the average lowest temperature in June, and the lowest temperature in October increased, which increased the periods for soft-shelled turtle growth and oviposition, accelerated its growth, thus were favorable to improvement of breeding benefit. The related climatic factors in the 2000s were obviously higher than those in the 1900s, which indicated that the climate change was more favorable to soft-shelled turtle breeding and its sustainable development in Nanfeng County. Because of the complex terrain as well as the heterogeneous distribution of light, temperature and water resources we suggested to select the areas with abundant heat resources and below elevation of 200 m in the middle of Nanfeng County. The breeding of soft-shelled turtle should start in April, egg sold and hatching should be from June to September, and the soft-shelled turtles should be sold after early November.