Biosynthesis, Metabolism and Application of 5-aminolevulinic Acid

doi:10.11923/j.issn.2095-4050.cjas2024-0217

Abstract

Abstract:

5-Aminolevulinic acid (5-ALA) is widely present in animals, plants, and microbial cells and serves as a key precursor for tetrapyrrole compounds. It participates in the synthesis of essential metabolites such as heme, vitamin B₁₂, and chlorophyll, exhibiting diverse physiological functions. This paper summarized the biosynthesis pathway of 5-ALA and its transport mechanism across different cell types, analyzed the functions and regulatory mechanisms of important downstream metabolites derived from 5-ALA, and reviewed the current applications of 5-ALA in pharmaceutical and agricultural fields. Furthermore, this paper highlighted existing challenges, including immaturity of biosynthesis technology and lack of standardized application protocols, and provided future research prospects to guide its potential applications in agriculture.

Key words: 5-aminolevulinic acid, biosynthesis, transport, metabolites, application field

YANG Yuting, CAI Shuang, YE Changchuan, QIAO Shiyan. Biosynthesis, Metabolism and Application of 5-aminolevulinic Acid[J]. Journal of Agriculture, 2025, 15(10): 53-64.

Figures/Tables 3

References 131

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