Abstract: Abstract: To study the chemical control of sugarcane borer and and to provide scientific basis for screening its efficient pesticides. The toxicity of thiamethoxam, monosultap and their mixture against Tetramoera schistaceana Snellen 2nd instar larvae were tested in the laboratory by sugarcane stem dipping methods, the results showed that both the thiamethoxam and monosultap had relatively high toxicity against Tetramoera schistaceana adults. Significant synergism was observed in the mixture of thiamethoxam and monosultap, with the ration of 1:18 showing the highest synergism. According to the proper proportion, a 3.8% GR synergistic formulation was manufactured, and the results of controlling after 45 days showed that the control effect were 80.1%, 85.4% at 55, 70 kg/hm2, respectively. These suggested monosultap thiamethoxam 3.8% GR be better as alternative pesticide on controlling sugarcane borer.