Abstract: In recent years, the wheat scab has become a severe epidemic around the middle and lower reaches of Yangtze River in China, and Fusarium graminearum has obvious resistance to benzimidazole fungicide carbendazim and its compounded agents. The authors selected 16 kinds of pesticides of 6 categories from registered and unregistered bactericides, conducted comparative experiments according to recommended dosage to screen the efficient fungicide to control the resistant strain, and also studied the best fungicides spray period, frequency and intervals. The results showed that: prochloraz, the mixture of triclopyricarb and tebuconazole, the mixture of tebucon azole and prochloraz and the mixture of JS399-19 and tebuconazole had good control effect on wheat scab, and the control efficiency was above 80% , which could be used as a replacement of carbendazim. The control efficiency of the mixture of tebuconazole and carbendazim, the mixture of prochloraz and carbendazim, tebuconazole, shenqinmycin and JS399-19 was 70%-80%, which was equal to or slightly better than that of carbendazim treatment, and they could be used as alternates. Shenqinmycin was a kind of antibiotic drugs, which had significant meanings to reduce the usage amount of chemical agent and environment stress. The results also showed the happen years of wheat scab, and the best spray period was the preliminary stage of flowering stage, the best pesticide application frequency was twice at the preliminary stage of flowering stage with a 5-7 days interval, and the best interval was 5-7 days.