Abstract: In order to promote the development of cassava industry and improve comparative economic benefit of cassava planting, the authors carried out high yield and high efficiency cultivation experiment and demonstration of cassava intercropping with watermelon in Guiping county from 2012 to 2015. This article summarized a set of cultivation techniques and analyzed the yield and economic benefits of cassava intercropping with watermelon. It showed that the economic benefits of cassava intercropping with watermelon was 110.1% higher than that of only planting cassava and was 90.8% higher than that of only planting watermelon in demonstration area, the economic benefits of cassava intercropping with watermelon was 129.0% higher than that of only planting cassava and was 77.5% higher than that of only planting watermelon in radiation area. The results of the study can provide a technical support for the standardized cultivation and production of cassava.