Abstract: The paper aims to study the cultivation effect of Psammosilene tunicoides W. C. Wu et C. Y. Wu under plastic mulching. 3 treatments of white plastic mulching, black plastic mulching and cultivation without mulching were carried. The results showed that plastic mulching could significantly improve the survival rate of seedling and increase the root weight in the first year. Compared with the cultivation without mulching, in the second year, the survival rate of seedling decreased significantly and the root weight had no significant difference, but in the third year, the survival rate of seedling and the root weight both decreased significantly. Therefore, plastic mulching cultivation can be taken in the first year, but not in the second and the third year. 3 years of consecutive cultivation under plastic mulching will lead to the final yield decrease.