Abstract: The range of somatic cell count (SCC) and the correlations between SCC and other milk components were discussed in this paper, so as to provide a reference for making the normal ranges of physical and chemical indexes of milk from Zhongdian cattle-yak. 92 milk samples were collected, 8 indexes including cattle-yak milk, such as milk fat, lactoprotein, lactose, SCC, milk urea nitrogen (MUN), milk freezing point (MFP), etc. were determined, and Pearson correlation between SCC and other milk components were analyzed. The results showed that the average contents of milk fat, lactoprotein, lactose, total solids and nonfat solids were 6.24%, 4.23%, 4.91%, 18.01% and 10.59%, respectively. It indicated that main nutritional components were high in milk of Zhongdian cattle-yak. The average SCC was 80.12 thousand/mL, and the individuals with SCC≤500 thousand/mL, 500 thousand/mL 0.05), respectively. It showed that SCC had a strong influence on the main nutritional components of milk. Zhongdian cattle-yak had an average MFP of -0.587℃, indicating that its milk products had low MFP, which might relate to the fact that cattle-yak had formed a mechanism to adapt to high altitude and cold climate. The average MUN was 7.52 mg/dL in cattle-yak milk. It indicated that protein diet used to feed cattleyak was insufficient or with poor quality. This study obtained milk SCC range and its correlations with other physical and chemical indexes, providing important reference for the quality control of milk from Zhongdian cattle-yak.