Abstract: Considering the ecological environment of Sichuan area, an experiment was conducted to breed new corn varieties with high yield, high quality, multi resistance and wide adaptability. According to the principle of gene recombination, the authors combined the local tropical germplasm with PB germplasm, which was rich in disease- resistant, lodging- resistant and drought- tolerant genes, and the integration was used as the innovative strategy for breeding. Inbred-line‘LSC 107’was successfully bred and the new corn hybrid‘Wande No.1’was bred by crossing‘LSC 107’with‘Yi 99-19’. The results showed that the corn hybrid had good performance, including high yield, good stability, high quality, excellent disease resistance and lodging resistance, and wide adaptation. So it was adaptable for planting in plain and hilly areas of Sichuan Province. With hybrid recombination between local tropical germplasm and PB inbred lines, the inbred-line had high general combining ability and strong adaptability, and the hybrid had high yield, high quality and wide adaptability, and had broad prospects of popularization and application.