Abstract: The main purpose of this paper is to improve cultivation techniques and explore yield potential of asparagus in Weifang ecological region. Under the combination of field experiment and laboratory analysis, asparagus growth and yield in high and low fertility blocks with different rates of nitrogen, phosphorous and potassium fertilizer were studied using‘Guanjun’of four- year- old as material. The results showed thatfertilization had no obvious stimulation effect in high fertility block when the content of soil organic, total nitrogen, available N, available P, available K was 1.36% , 0.091% , 41.0 mg/kg, 13.4 mg/kg, 140 mg/kg, respectively. Fertilization had an obvious stimulation effect in low fertility block, the best ratio of nitrogen, phosphorous and potassium fertilizer was 10: 7: 9. The suitable index of organic fertilizer, N, P2O5 and K2O were 60000 kg/hm2, 450 kg/hm2, 315 kg/hm2 and 405 kg/hm2 under target yield of 15000 kg/hm2, organic fertilizer and 60% percent chemical fertilizer should be applied at shoot harvesting, and the rest 40% chemical fertilizer should be used as additional fertilizer one month later.