Abstract: To make clear the changing trend of soil microelement in Panzhihua tobacco-growing area, 170 soil samples of top layer were detected and analyzed based on soil data from 2009 to 2010. The results showed that compared with five years ago, the average content of soil available Zn decreased by 13.5%, in which, that of Miyi County increased by 37.4%, that of Yanbian County and Renhe County reduced by 15.6% and 38.2%, respectively. Soil available B in Panzhihua increased by 30%, according to the classification of soil available B, 72.29% of the soil in Panzhihua was lack of available B, and the available B lacking area proportion in Renhe, Miyi and Yanbian tobacco-growing area was 70.58%, 61.23% and 63.75%, respectively. Soil water soluble Cl content decreased by 29.02% in Panzhihua tobacco- growing area, but that in Miyi Country increased by 27.04%, and that in Yanbian and Renhe decreased by 38.2% and 33.8%, respectively.