Abstract: Grapes have strong adaptability, early fruit yield, flower bud super node differentiation and many times fruiting a year. In this paper, the physiological and biochemical basis of double harvest of grape in a year, the effects of temperature, pruning, medicaments and cultivation measures on the secondary fruit production of grape and the effects of secondary fruit production on the yield and fruit quality were summarized in detail. The way and node of inducing flower bud differentiation and germination are very important for developing the two results of grape development. However, due to the short time of popularization and application of the technology in China, most of the growers are not mature enough, and the climatic conditions and variety characteristics are highly demanded, resulting in slow development in actual production. In view of the present situation of production and research, the author suggests that the physiological and biochemical mechanism of secondary fruiting of grapes should be studied in combination with climatic conditions and variety characteristics, so as to speed up the introduction or breeding of more grape varieties with good flower bud differentiation and good quality to meet the diversified needs of the market, and for the successful grape varieties and corresponding cultivation management. In order to provide a theoretical basis for the production of grape secondary fruit, the model should be applied in small areas first, mastered and then mass produced, emphasized the role of demonstration and popularization, and strengthened the technical training and guidance for growers.