Abstract: In order to effectively control leaf scab disease of sweetpotato, experiments of six pesticides of Thiophanate-Methyl, Carbendazim, Benomy, Mancozeb, Streptomycin-Sulfate，Thiodiazole-Copper and Carbendazim-Sulfur were carried out to compare the leaf scab disease control efficacy on sweetpotato. The results showed that 50%Carbendazim-sulfur with 500 times, 50%Carbendazim-Sulfur with 500 times and 70%Thiophanate-Methyl with 600 times had better control effects on sweetpotato scab disease.