Abstract: In order to investigate the comprehensive effect of different cultivation factors on‘suiza No.7’ sorghum, with three factors quadratic current rotation revolving design, the models were established on the effects of density, fertilizer amount and seed-date on yield of‘Suiza No.7’Sorghum. According to the testing results of DPS, the quadratic regression model had better simulation effect. The mathematical model was: Y= 8218.18312-446.78324X12-287.68422X22-567.34494X32. The results showed that the influencing order of three factors on yield was sowing time >planting density>fertilizer. Two-factor interaction analysis showed that there was a positive interaction between sowing time and planting density, planting density and fertilizer, sowing time and fertilizer to some extent. By computer simulating, the cultivation combination to obtain seed yield above 7330 kg/hm2 for‘Suiza No.7’was being planted at 7th to 12th May with planting density of 17.154- 18.846×104 plants/km2 and fertilizer rate of 211.8-150.7 kg/hm2.