Abstract: In order to achieve summer maize high yield and fertilization simplification in moisture soil area in eastern Henan, the effect of slow release fertilizer on summer maize yield, economic benefit and stress resistance was analyzed by field experiment and demonstration. The results of test in Shangshui and Zhoukou showed that slow release fertilizer with nitrogen proportion accounting for 45% could increase thousand seed weight and kernels number per spike, compared with that under traditional fertilization, the thousand seed weight increased by 28 g, kernels number per spike increased by 16. Slow release fertilizer promoted the absorption of nutrients of summer maize, and it could maintain the balance of nitrogen nutrient in soil, it had significant yield and efficiency increasing effect; compared with traditional fertilization, the application of slow release fertilizer (seed and fertilizer applied in the same time) increased the yield by 13.5%, increased the benefit by 1920 yuan/hm2; compared with normal fertilizer, the slow release fertilizer increased yield by 10.3%, increased the benefit by 1215 yuan/ hm2. The study provided reference for the promotion of slow release fertilizer in Zhoukou.