Abstract: Abstract: To reveal the effect of quicklime on the acid soil cultivated with flue-cured tobacco in Panzhihua city, Sichuan province, a two years continuous field experiment with four different amount of quicklime including 450, 900, 1,350 and 1,800 kg/hm2 were established, and the soil nutrition and flue-cured tobacco production traits were monitored. The result showed that the application of quicklime in acid soil could significantly increase the soil pH. Meanwhile, the soil nutrients, flue-cured tobacco yields, flue-cured tobacco economic returns and chemical composition of tobacco leaves were all also significantly influenced by using of quicklime. Among the four different amounts of quicklime, the soil nutrients contents, the flue-cured tobacco yields and quality were all reached the highest under the amount of 1,350 kg/hm2, furthermore, the chemical components of the flue-cured tobacco leaves were also very similar to those in the high quality tobacco.