Abstract: The aim is to solve leaf premature senescence of conventional millet and hybrid millet at later growth stage in practical production. The conventional millet‘Jingu 21’and the hybrid strain‘4A/H51’were used as materials. Taking water as the control, 8 plant growth regulators and 3 foliar fertilizers were sprayed. The chlorophyll concentration, photosynthetic rate and main agronomic traits were detected, and the effects of different agentia on physiological and agronomic indexes of different millet varieties were studied. The results showed that spraying Sea Chlorophyll, Power Plants 2013 and Genwang could improve chlorophyll content and increase photosynthetic rate. The transport and distribution of assimilation substance was effectively regulated. Compared with the control, the increasing extent of hybrid millet was higher than that of conventional millet, indicating that the agentia could effectively control premature senescence. Sea Chlorophyll enabled parietal lobe width significantly wider than the control, Genwang and Power Plants 2013 could thicken sheath stem, Power Plants 2013 could reduce plant height and so on, which met the current need of millet production research. Thus, the utilization of plant growth regulators and foliar fertilizers can solve the problem of premature senescence in millet production, especially benefit the large-scale promotion of hybrid millet.