Abstract: In view of the problems existing in production, combined with many years of experiment and demonstration results, the cultivation technology and high yield creation application are optimized. The regression relationship between N,P,K, density and yield of Maize in high yield cultivation was discussed.The results showed that the high-yield group yield structure index of "Han Yu 66" was 63000~67500 plant /hm 2, 450~600 grains per panicle, grain weight of 325~345g, 14~18 row number per spike, 33~35 grain number of row grain, 160~210 g of single spike grain weight, 17~22 cm of ear length. "HanYu 66 2, high quality organic fertilizer 60-75m3/hm2, N 115-150kg/hm2, P2O5 300-375kg/hm2, K2O 225-300kg/hm2. We stipulated the characteristics of Han Yu 66, the climate and soil conditions of production, the planting techniques, the fertilization technology, the field management, the pest control and the harvest time. We have made the high and efficient cultivation technical regulations of the "Hanyu 66", which provided the theoretical basis and technical support of transformation of "high input and low yield" to "high yield and high efficiency".