Abstract: In order to determine the control effect and safety of six kinds of soil-applied herbicides on sunflower field weed, and screen the suitable one for sunflower field, field plot trial was used in this experiment. The results showed that 960 g/L S-metolachlor EC, 900g/L Acetochlor EC have better control effect on annual gramineous weeds and are safety to sunflower; 330 g/L Pendimethalin EC has better control effect on both gramineous weeds and broadleaf weeds and are safety to sunflower; 75% thifensulfuron methyl WG and 50% flumioxazin WP have better control effect on broadleaf weeds and are safety to sunflower, while 80% oxadiargyl WP has effect on fresh weight during seeding stage and final yields. In conclusion, 960 g/L S-metolachlor EC, 900g/L Acetochlor EC, 330 g/L Pendimethalin EC, 75% thifensulfuron methyl WG and 50% flumioxazin WP can be used on sunflower field, while 80% oxadiargyl WP is not suitable for sunflower.