Abstract: Based on field experiments of multi-factor orthogonal designed, machine picked cottonScultivation techniquesSwere studied in the area along the Yangtze RiverSin Anhui Province, in order toSestablish the mode ofSmachine picked cottonScultivation techniquesSin the area. The results show that varieties, sowing date and planting density influence the lint yield of machine picked cotton along the Yangtze River significantly, and DPC,SN andSsquare removalSmeasures influence the lint yieldSto varying degrees. Machine picked cottonScultivation techniquesSwere optimized in the area along the Yangtze RiverSin Anhui Province, which includes that selecting of early maturing varieties, such as Zhongmiansuo 50 and Jishou 50, direct seeding in late May, with planting density ranging from 105 000 to 112 500 plants per ha, the content of N about 180 kg/ha, the content of DPC ranging from 180 to 270 g/ha. The specificSmethods of fertilization andSchemical controlSshould consider many factors,Ssuch as soil, growth, weather, etc. If possible, the early or late buds can be removed, in order to shorten the boll opening stage of machine picked cotton, which can be more easily mechanized harvesting of cotton once.